Presentation: Selective Immune Reconstitution Treatment: Mechanism of Action, Efficacy and Safety in RMS

Thomas P. Leist, MD, PhD
Professor of Neurology
Chief, Division of Clinical Neuroimmunology
Director, Comprehensive Multiple Sclerosis Center
Thomas Jefferson University
Philadelphia, PA

Learning Objectives

After viewing this presentation, the participant should be able to:
  • Review approaches and goals of treatment in MS
  • Discuss pathophysiologic considerations surrounding immune reconstitution therapies (IRT) and selective immune reconstitution therapy (SIRT) approaches in MS
  • Summarize currently available clinical efficacy and safety data
  • Identify future areas of research


Target Audience

Neurologists and neuroscience nurses, as well as other clinicians practicing in MS comprehensive care centers, freestanding MS centers, private and group practices, MS academic and research programs, rehabilitation centers, VA MS COE programs, and long-term care facilities.


Requirements for Successful Completion

To successfully complete this activity for CE credit, the participant will:
1. Take the pretest
2. Review the content in the presentation
3. Complete the posttest with a score of at least 3 correct answers
4. Fill out a brief evaluation

Upon completion of the requirements 1 – 4, a CE certificate will be available for download.

Release & Expiration Dates
December, 2018 to December, 2019


Disclosure Information and Off-Label Uses
It is the policy of Letters & Sciences to ensure balance, independence, objectivity, and scientific rigor in all their sponsored educational activities. All faculty members participating in this activity are expected to disclose to the participants any real or perceived conflicts of interest related to the content of their presentations.

It is not assumed that these relationships or financial interests will have an adverse impact on the faculty presentations. They simply are noted here to fully inform course participants.

Claire S. Riley, MD, Chair
  • Has served as advisor or consultant for: Biogen Idec, Celgene, Genzyme, Genentech/Roche, TG Therapeutics, Teva Neuroscience

Patricia K. Coyle, MD
  • Has served as consultant for: Accordant, Bayer, Biogen, Celgene, EMD Serono, Genentech/Roche, Genzyme/Sanofi, Novartis, Teva
  • Has received research support from: Actelion, Alkermes, Biogen, Genentech/Roche, MedDay, NINDS, Novartis

Rebecca S. Farber, MD
  • Has received research support from: Genentech

Stephen C. Krieger, MD
  • Has served as a consultant for: Acorda, Bayer, Biogen, EMD Serono, Celgene, Genentech, Genzyme, Mallinckrodt, Novartis, Teva

Thomas P. Leist, MD, PhD
  • Has served as a consultant/ speaker for: Biogen, EMD Serono, Genentech, Novartis, Teva
  • Has received research/clinical trial support from: Actelion, Alkermes, Biogen, Chugai, Novartis
  • Serves as Chair for the MSBase Foundation Board

Carrie Lyn Sammarco, DrNP, FNP-C, MSCN
  • Has served on the speaker’s bureau for: Avadel, Biogen, Genentech

Wendy S. Vargas, MD
  • Has received grants/research support from: The National MS Society, Teva Pharmaceuticals
  • Has served as a consultant for Alexion Pharmaceuticals

External Review
In accordance with the policies of Letters & Sciences, and in compliance with the standards of ANCC to identify and resolve any potential conflicts of interest, to assure fair balance, Independence, and objectivity, and to instill scientific rigor in all accredited activities, all presentations with any potential for conflict of interest, have been reviewed by external reviewers. These external reviewers, who have no potential conflicts of interest, have determined that no bias exists in these presentations. The external reviewers are:

Shannon L. DeVita, MSN, RN, CNL, DNP(c)
University of San Diego
San Diego, California

Michele Nichols, PharmD
Pharmacy Consultant
Private Practice
Raritan, New Jersey

Accreditation Statements
Joint Acreditation Statement

In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine (PIM) and Letters & Sciences. Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician Continuing Medical Education
The Postgraduate Institute for Medicine designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)®. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

To receive acknowledgement for participating in this activity, learners must complete the evaluation form.

Continuing Nursing Education
Letters & Sciences is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation. Each activity has been designated for 0.5 contact hours.

Nonendorsement of Products
The participant is advised that the educational content contained herein was developed by and reflects the opinions of the presenters and faculty, and does not necessarily reflect the opinions or recommendations of the educational provider or the commercial supporter. Accredited status does not imply endorsement by Letters & Sciences or the American Nurses Credentialing Center’s Commission on Accreditation of any commercial product discussed/displayed in conjunction with the educational activity.


Commercial Support

This program is supported by an educational grant from EMD Serono.
EMD Serono Inc. is an affiliate of Merck KGaA, Darmstadt, Germany.



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